Double Marker Test in Pune
Price, Symptoms, Normal Range
Double Marker Test is a blood test that screens for Down Syndrome and other chromosomal abnormalities in a developing fetus. It costs Rs.2900.0 .
Updated At : 2023-11-11T19:24:52.443+05:30
4 Key Points
What can be detected by the double marker test?
- The double marker test is used to detect the risk of two genetic diseases in the baby : Edwards's Sydrome(Trisomy 18) and Trisomy 21(Down's Syndrome)
- Both these diseases can be detected before the baby is born, by simply checking levels of some proteins in the mother's blood.
- If the levels of the proteins are higher than a given threshold, it increases the risk of the baby having either or both of these diseases.
- It is important to note that the Double Marker Test is not confirmatory, but constitutes a part of routine Genetic Screening During Pregnancy. If risk is less than the cut-off it does not rule out the possibility of Down's Syndrome or Trisomy 18.
What is Down's Syndrome (Trisomy 21)
- Down's Syndrome is a condition in which the baby has 3 copies of chromosome number 21. Normally there should be only 2 copies.
- <table class="striped"> <thead> <tr> <th>Feature</th> <th>Description</th> </tr> </thead> <tbody> <tr> <td>Intellectual Disability</td> <td>Individuals with Down's Syndrome typically have mild to moderate intellectual disability.</td> </tr> <tr> <td>Distinct Facial Features</td> <td>Characteristic facial features include slanted eyes, small ears, and a flat nasal bridge.</td> </tr> <tr> <td>Hypotonia</td> <td>Low muscle tone often leads to poor muscle strength and coordination.</td> </tr> <tr> <td>Short Stature</td> <td>People with Down's Syndrome tend to be shorter in height than average.</td> </tr> <tr> <td>Heart Defects</td> <td>Many individuals have congenital heart defects that may require medical intervention.</td> </tr> <tr> <td>Gastrointestinal Issues</td> <td>Digestive problems and gastrointestinal anomalies may be present.</td> </tr> <tr> <td>Increased Susceptibility to Infections</td> <td>Down's Syndrome individuals are more vulnerable to respiratory and other infections.</td> </tr> <tr> <td>Developmental Delays</td> <td>Children with Down's Syndrome may experience delays in motor, speech, and cognitive development.</td> </tr> </tbody> </table>
What is Edward's Syndrome (Trisomy 18)
- Edward's Syndrome is a genetic disorder in which the baby has 3 copies of chromosome number 18. Normally there should be only 2 copies.
- <table class="striped"> <thead> <tr> <th>Feature</th> <th>Description</th> </tr> </thead> <tbody> <tr> <td>Intellectual Disability</td> <td>Individuals with Edwards Syndrome may have intellectual and developmental delays.</td> </tr> <tr> <td>Distinct Facial Features</td> <td>Characteristic facial features may include a small jaw, low-set ears, and clenched hands.</td> </tr> <tr> <td>Heart Defects</td> <td>Many individuals have severe heart defects that often require medical treatment.</td> </tr> <tr> <td>Growth Retardation</td> <td>Individuals with Edwards Syndrome usually have slow growth and low birth weight.</td> </tr> <tr> <td>Rocker Bottom Feet</td> <td>The feet may have a rocker-bottom appearance due to an abnormal shape of the sole.</td> </tr> <tr> <td>Clenched Hands</td> <td>Babies may have clenched fists with overlapping fingers and a characteristic hand position.</td> </tr> <tr> <td>Kidney and Urinary Tract Abnormalities</td> <td>Abnormalities in the kidneys and urinary tract are common in individuals with Edwards Syndrome.</td> </tr> <tr> <td>Feeding Difficulties</td> <td>Feeding difficulties are often present due to poor muscle tone and coordination.</td> </tr> </tbody> </table>
Is the Double Marker Test same as Non-Invasive Prenatal Screening (NIPT)?
- No, the double marker test and NIPT are two completely different tests.
- The Double Marker Test was first introduced in the mid-1990's and it checks the levels of two proteins in the mother's blood and tries to estimate the chances of the fetus having a chromosomal abnormality. In contrast, the NIPT is designed to isolate the fetus's DNA from the mothers blood, and directly checks this DNA for chromosomal abnormalities.
- NIPT is a newer test, and since it directly checks the fetu's DNA it is more sensitive than the Double Marker Test. As such the double marker test is now largely replaced by the quadruple marker test or NIPT in most centers.
Table of Contents
What is Double Marker Test
The Double Marker Test is a prenatal blood test that measures two specific hormones, beta-HCG and PAPP-A, in a pregnant womans blood. It is performed between 10-14 weeks of pregnancy and is used to screen for Down syndrome and other chromosomal abnormalities in the fetus. The test involves a simple blood draw and results are usually available within a few days. Abnormal results may require further testing or genetic counseling.
Do I need this test?
Let's find out whether you need the Double Marker Test test. Answer the following 5 questions and get a free instant result!
Which symptoms are related to Double Marker Test?
If you have Abnormal Bleeding,Swollen Ankles,Excessive Fatigue,Abdominal Pain,Dizziness, you may need to get tested.
Here is the complete list of symptoms
Who should do this test?
Double Marker Test should be done for pregnant women who are at high risk of having a baby with chromosomal abnormalities, such as Down syndrome.
- Women who are over the age of 35 should consider Double Marker Test as they are at an increased risk of having a baby with chromosomal abnormalities.
- Women who have a family history of chromosomal abnormalities or have had a previous pregnancy with chromosomal abnormalities should also undergo Double Marker Test.
What to do if the test is abnormal?
- The first step would be to confirm the accuracy of the test results by repeating the test or performing additional tests to rule out any errors or contamination during the testing process.
- Consult with a specialist, such as a perinatologist or genetic counselor, who can explain the results in detail and provide further guidance on the next steps. They may recommend additional testing, such as an amniocentesis or chorionic villus sampling, to obtain more detailed information about the health of the fetus.
- Depending on the severity of the abnormal results and the overall health of the mother and fetus, the specialist may recommend various treatment options, such as medication, surgery, or close monitoring throughout the pregnancy. It is important for the patient to follow their doctors advice closely and ask any questions they may have to fully understand the situation and make informed decisions regarding their health and pregnancy.
In which diseases is Double Marker Test abnormal?
Trisomy 21 (Down Syndrome)
Neural Tube Defects
Trisomy 21 (Down Syndrome)
Neural Tube Defects
Normal Range - Double Marker Test
Normal Ranges in Males
>= 0 years
Normal Ranges in Females
>= 0 years
|>= 0 years||*|
|>= 0 years||*|
What are the normal ranges for the Double Marker Test ?
|Normal Ranges for Double Marker Test|
|Disease Name||Risk Cutoff|
|The normal range for Trisomy 21 (Down's syndrome)||less than 1/230|
|The normal range for Trisomy 18||less than 1/100|
Currently no treatment options details are avaialble for this report,check back later or consult your doctor
|Sample Type Required||serum|
|Principle of Measurement||CLIA|
|Units of Measurement||-|