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Double Marker Test in Pune: Price, Symptoms, Normal Range

Double Marker Test in Pune

Price, Symptoms, Normal Range

Double Marker Test is a blood test that screens for Down Syndrome and other chromosomal abnormalities in a developing fetus. It costs Rs.2900.0 .

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Updated At : 2024-01-24T03:49:29.250Z

4 Key Points

  • What can be detected by the double marker test?

  • The double marker test is used to detect the risk of two genetic diseases in the baby : Edwards's Sydrome(Trisomy 18) and Trisomy 21(Down's Syndrome)
  • Both these diseases can be detected before the baby is born, by simply checking levels of some proteins in the mother's blood.
  • If the levels of the proteins are higher than a given threshold, it increases the risk of the baby having either or both of these diseases.
  • It is important to note that the Double Marker Test is not confirmatory, but constitutes a part of routine Genetic Screening During Pregnancy. If risk is less than the cut-off it does not rule out the possibility of Down's Syndrome or Trisomy 18.
  • What is Down's Syndrome (Trisomy 21)

  • Down's Syndrome is a condition in which the baby has 3 copies of chromosome number 21. Normally there should be only 2 copies.
  • <table class="striped"> <thead> <tr> <th>Feature</th> <th>Description</th> </tr> </thead> <tbody> <tr> <td>Intellectual Disability</td> <td>Individuals with Down's Syndrome typically have mild to moderate intellectual disability.</td> </tr> <tr> <td>Distinct Facial Features</td> <td>Characteristic facial features include slanted eyes, small ears, and a flat nasal bridge.</td> </tr> <tr> <td>Hypotonia</td> <td>Low muscle tone often leads to poor muscle strength and coordination.</td> </tr> <tr> <td>Short Stature</td> <td>People with Down's Syndrome tend to be shorter in height than average.</td> </tr> <tr> <td>Heart Defects</td> <td>Many individuals have congenital heart defects that may require medical intervention.</td> </tr> <tr> <td>Gastrointestinal Issues</td> <td>Digestive problems and gastrointestinal anomalies may be present.</td> </tr> <tr> <td>Increased Susceptibility to Infections</td> <td>Down's Syndrome individuals are more vulnerable to respiratory and other infections.</td> </tr> <tr> <td>Developmental Delays</td> <td>Children with Down's Syndrome may experience delays in motor, speech, and cognitive development.</td> </tr> </tbody> </table>
  • What is Edward's Syndrome (Trisomy 18)

  • Edward's Syndrome is a genetic disorder in which the baby has 3 copies of chromosome number 18. Normally there should be only 2 copies.
  • <table class="striped"> <thead> <tr> <th>Feature</th> <th>Description</th> </tr> </thead> <tbody> <tr> <td>Intellectual Disability</td> <td>Individuals with Edwards Syndrome may have intellectual and developmental delays.</td> </tr> <tr> <td>Distinct Facial Features</td> <td>Characteristic facial features may include a small jaw, low-set ears, and clenched hands.</td> </tr> <tr> <td>Heart Defects</td> <td>Many individuals have severe heart defects that often require medical treatment.</td> </tr> <tr> <td>Growth Retardation</td> <td>Individuals with Edwards Syndrome usually have slow growth and low birth weight.</td> </tr> <tr> <td>Rocker Bottom Feet</td> <td>The feet may have a rocker-bottom appearance due to an abnormal shape of the sole.</td> </tr> <tr> <td>Clenched Hands</td> <td>Babies may have clenched fists with overlapping fingers and a characteristic hand position.</td> </tr> <tr> <td>Kidney and Urinary Tract Abnormalities</td> <td>Abnormalities in the kidneys and urinary tract are common in individuals with Edwards Syndrome.</td> </tr> <tr> <td>Feeding Difficulties</td> <td>Feeding difficulties are often present due to poor muscle tone and coordination.</td> </tr> </tbody> </table>
  • Is the Double Marker Test same as Non-Invasive Prenatal Screening (NIPT)?

  • No, the double marker test and NIPT are two completely different tests.
  • The Double Marker Test was first introduced in the mid-1990's and it checks the levels of two proteins in the mother's blood and tries to estimate the chances of the fetus having a chromosomal abnormality. In contrast, the NIPT is designed to isolate the fetus's DNA from the mothers blood, and directly checks this DNA for chromosomal abnormalities.
  • NIPT is a newer test, and since it directly checks the fetu's DNA it is more sensitive than the Double Marker Test. As such the double marker test is now largely replaced by the quadruple marker test or NIPT in most centers.

What is Double Marker Test

The Double Marker Test is a prenatal blood test that measures two specific hormones, beta-HCG and PAPP-A, in a pregnant womans blood. It is performed between 10-14 weeks of pregnancy and is used to screen for Down syndrome and other chromosomal abnormalities in the fetus. The test involves a simple blood draw and results are usually available within a few days. Abnormal results may require further testing or genetic counseling.

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Do I need this test?

Let's find out whether you need the Double Marker Test test. Answer the following 5 questions and get a free instant result!

Have you experienced any unusual fatigue or dizziness lately
Have you experienced any unusual fatigue or dizziness lately

Have you had any abdominal pain, cramping, or bloating
Have you had any abdominal pain, cramping, or bloating

Are you having any unusual swelling or fluid retention
Are you having any unusual swelling or fluid retention

Are you having any vaginal bleeding or spotting
Are you having any vaginal bleeding or spotting

Have you had any changes in your vision or hearing
Have you had any changes in your vision or hearing

Result :

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Which symptoms are related to Double Marker Test?

If you have Abdominal Pain,Nausea,Blurred Vision,Joint Pain, you may need to get tested.

Here is the complete list of symptoms

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Who should do this test?

Double Marker Test should be done for pregnant women who are at high risk of having a baby with chromosomal abnormalities, such as Down syndrome.

  • Women who are over the age of 35 should consider Double Marker Test as they are at an increased risk of having a baby with chromosomal abnormalities.
  • Women who have a family history of chromosomal abnormalities or have had a previous pregnancy with chromosomal abnormalities should also undergo Double Marker Test.

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What to do if the test is abnormal?

  • The first step would be to confirm the accuracy of the test results by repeating the test or performing additional tests to rule out any errors or contamination during the testing process.
  • Consult with a specialist, such as a perinatologist or genetic counselor, who can explain the results in detail and provide further guidance on the next steps. They may recommend additional testing, such as an amniocentesis or chorionic villus sampling, to obtain more detailed information about the health of the fetus.
  • Depending on the severity of the abnormal results and the overall health of the mother and fetus, the specialist may recommend various treatment options, such as medication, surgery, or close monitoring throughout the pregnancy. It is important for the patient to follow their doctors advice closely and ask any questions they may have to fully understand the situation and make informed decisions regarding their health and pregnancy.

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In which diseases is Double Marker Test abnormal?

Trisomy 21 (Down Syndrome)
Maternal Diabetes
Chromosome Abnormalities
Neural Tube Defects
Rh Incompatibility
Maternal Infections
Fetal Anomalies

Double Marker Test Normal Range - Age Wise

Double Marker Test Normal Ranges in Males | Double Marker Test Normal Ranges in Men
Age Range
>= 0 years *

Double Marker Test Normal Ranges in Females | Double Marker Test Normal Ranges in Women
Age Range
>= 0 years *

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What are the normal ranges for the Double Marker Test ?

Normal Ranges for Double Marker Test
Disease Name Risk Cutoff
The normal range for Trisomy 21 (Down's syndrome) less than 1/230
The normal range for Trisomy 18 less than 1/100

Treatment options

Currently no treatment options details are avaialble for this report,check back later or consult your doctor

Technical information

Parameter Details
LOINC Codes 2857-1
Sample Type Required serum
Principle of Measurement CLIA,date,manual,calculated
Units of Measurement ng/ml,mIU/ml,-,kg,ratio
Double Marker Test Cost in Pune

What is the Cost of Double Marker Test?

The test costs Rs.2900.0

Details about cost price of Double Marker Test

  • Free home visit for sample collection for Double Marker Test in all parts of Pune City is included in the cost price.
  • Kindly note that we do not charge any visit charges as most other labs. This is because the cost of Double Marker Test in Pune is already high and we do not wish to levy additional charges on patients.
  • The cost price of Double Marker Test is updated only in case of sudden changes in government rules. You are requested to check the latest cost price of Double Marker Test as charged by Pathofast on this page.
  • All online forms of payment are available at our lab, including Gpay, Payumoney, credit and debit card as well as cheque payment.

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How to book Double Marker Test in Pune?

Book a free home visit in Pune online, call our lab at 020 49304930 or get in touch using Watsapp.

Pathofast offers Double Marker Test at our center in Manisha Terrace, Moledina Road, Pune, Camp, India
Our diagnostic center in Pune and pathology lab in Pune, is known for its exceptional hygiene, polite staff and quick reports
Our Pune Center, is located close to the railway station and the Swargate Central Bus Depot, as well as the new Metro Lines
Please choose an option below to proceed with your booking:

Near which locations or areas of Pune is Double Marker Test available?

Pathofast offers lab test service for Double Marker Test near : Camp, Koregaon Park, Kalyani Nagar, Viman Nagar, Aundh, Baner, FC Road, Tilak Road, Ravet, Aundh, Pimpri Chinchwad, Nagar Road, Dhole Patil Road.

Locations for free home sample collection near you in Pune for Double Marker Test

Pathofast Lab Pune offers free home sample collection in the areas on the map for Double Marker Test. Find directions now or use the online booking links.

What are the Advantages of choosing a lab near you for blood test services?
  • Choosing a nearby lab reduces the time it takes for the sample to be transported
  • This leads to reduced sample deterioration.
  • While most patients are unaware, blood samples must be transported under strictly controlled temperature, and choosing a lab near you makes this easier to achieve.
  • Even if the lab does not adhere to temperature control, the time spent between sample collection and analysis reduces and this is more likely to produce more accurate results

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Dr.Bhargav Raut - Profile Image

Reviewed By -

Dr.Bhargav Raut is a qualified Pathologist, with over 5 years of experience in the field
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