Creatinine 8.4 mg/dl means : causes, treatment, GFR calculation
In this article we discuss what a creatinine value of 8.4 mg /dl means, what are its causes and how to calculate your estimated Glomerular Filtration Rate based on the GFR, as well its implications on your kidney health. We also answer the question about whether a Creatinine level of 8.4 is dangerous, good or bad.Published Date : 2023-07-15T00:31:57.337Z
Updated Date : 2024-04-11T19:29:34.247+05:30
Table of Contents
What is Creatinine?
How is creatinine measured?
What does a creatinine of 8.4 mg/dl mean in men?
What does a creatinine of 8.4 mg/dl mean in women?
Is creatinine 8.4 dangerous?
What is the normal range and is a creatinine of 8.4 mg/dl normal?
What could cause a creatinine level of 8.4?
What other tests should be done if creatinine level is 8.4?
What is the relation between creatinine and kidney function?
Why do doctors ask for GFR if my creatinine level is 8.4?
What is my GFR if my creatinine level is 8.4?
References
Recommended Tests
What is Creatinine?
Serum creatinine is a substance that our body naturally produces as a result of muscle activity. It is formed when our muscles break down a molecule called creatine phosphate. The interesting thing about serum creatinine is that it is produced in a steady and constant manner, which means the amount of creatinine in our blood remains relatively stable over time. The level of serum creatinine is influenced by factors like our muscle mass. Generally, men tend to have higher levels of serum creatinine compared to women because they typically have more muscle mass. On the other hand, during pregnancy, the levels of serum creatinine tend to be lower due to the changes happening in a woman's body during that time. Doctors often measure serum creatinine levels to assess kidney function because our kidneys play a crucial role in filtering and removing this substance from our blood. By analyzing the amount of serum creatinine in our blood, healthcare professionals can gain insights into the health of our kidneys and detect any potential issues.1
How is creatinine measured?
A serum creatinine lab test is a simple blood test that helps measure the levels of creatinine in your body. Before the test, it is important to avoid eating a large amount of meat or taking certain medications, as they can affect the results. During the lab test, a trained healthcare professional will draw a small amount of blood from your arm using a needle. This blood sample will then be sent to the lab, where a machine called a spectrophotometer will measure the concentration of creatinine in your blood. This test is commonly done to check the health of your kidneys, as high levels of creatinine can indicate kidney problems.
What does a creatinine of 8.4 mg/dl mean in men?
The normal range for creatinine in women is between 0.73 and 1.18. A creatinine value of 8.4 mg/dl is considered very dangerous. It is highly recommended that you go to the hospital right away and you may need dialysis. It's important not to try to treat yourself.3,4
What does a creatinine of 8.4 mg/dl mean in women?
The normal range for creatinine in women is between 0.55 and 1.02. If your creatinine level is 8.4 mg/dl, it is considered very dangerous. It is highly recommended that you go to the hospital right away and you may need dialysis. Do not try to treat yourself.3,4
Is creatinine 8.4 dangerous?
A creatinine of may be dangerous depending on your gender and age. The tables below highlight the likelihood of a creatinine of being dangerous for different age groups in both men and women. We provide the following tables, based on the estimated GFR corresponding to the value of creatinine.
Table of danger posed by Creatinine 8.4 in male across different ages
| Age Group | Is Creatinne of 8.4 dangerous? |
|---|---|
| 25yrs - 95 yrs | very dangerous, Get immediate medical advice and treatment. |
Table of danger posed by Creatinine 8.4 in female across different ages
| Age Group | Is Creatinne of 8.4 dangerous? |
|---|---|
| 25yrs - 95 yrs | very dangerous, Get immediate medical advice and treatment. |
What is the normal range and is a creatinine of 8.4 mg/dl normal?
The normal range for creatinine in men is 0.73 to 1.18 mg/dl, and in women it is 0.55 to 1.02 mg/dl2. Based on these ranges, a creatinine level of 8.4 is considered abnormal.
What could cause a creatinine level of 8.4?
- Acute kidney injury: Sudden loss of kidney function due to various causes such as dehydration, severe infection, or medication toxicity.
- Chronic kidney disease: Long-term damage to the kidneys leading to reduced kidney function.
- Renal artery stenosis: Narrowing of the arteries that supply blood to the kidneys, causing decreased blood flow and impaired kidney function.
- Glomerulonephritis: Inflammation of the tiny filters in the kidneys, leading to impaired kidney function.
- Pyelonephritis: Kidney infection that can cause damage to the kidneys.
- Urinary tract obstruction: Blockage in the urinary tract that impairs the flow of urine, leading to kidney damage.
- Polycystic kidney disease: Inherited disorder causing the growth of cysts in the kidneys, leading to kidney damage over time.
- Interstitial nephritis: Inflammation of the kidney tubules and surrounding structures, often caused by medications or autoimmune disorders.
- Nephrotic syndrome: Kidney disorder characterized by excessive protein loss in urine, leading to impaired kidney function.
- Hemolytic uremic syndrome: Rare condition where red blood cells are destroyed and clog the kidney's filtering system, causing kidney injury.
What other tests should be done if creatinine level is 8.4?
Serum Electrolytes
A creatinine level of 8.4 mg/dl indicates severe kidney dysfunction. The Serum Electrolytes test is crucial as it measures the levels of essential minerals like sodium, potassium, and chloride, which can become imbalanced in kidney disease. Identifying electrolyte imbalances helps healthcare providers manage and treat the patient's condition effectively.
Blood Urea
The Blood Urea test is important because it measures the amount of urea nitrogen in the blood, which is a waste product produced by the liver during protein metabolism. A high level of blood urea indicates impaired kidney function and could be a result of conditions like kidney disease or dehydration. Therefore, when combined with the creatinine test, the Blood Urea test helps evaluate kidney health and determine the severity of kidney dysfunction.
Estimated GFR
The estimated GFR (glomerular filtration rate) test is important because it helps determine the kidney function in individuals with high creatinine levels, such as 8.4 mg/dl. It provides an estimate of how well the kidneys are filtering waste from the blood and can help diagnose kidney disease or monitor its progression. The test is crucial in guiding treatment decisions and assessing the overall health of the kidneys.
HBA1C
The HbA1c test is important in this case as it measures the average blood sugar levels over a period of time, usually the past 2-3 months. It helps in assessing long-term glycemic control and diagnosing or monitoring diabetes. For a patient with a high creatinine level, this test can provide valuable information about their overall blood sugar management and guide treatment decisions towards better kidney health.
LDH
The LDH (lactate dehydrogenase) test is important in this scenario because it is commonly used to assess kidney function. Elevated levels of LDH can indicate renal damage or dysfunction, which may help explain the high creatinine level. Additionally, LDH is a marker for tissue damage and can provide insights into the overall health status and potential underlying conditions of the patient.
Random Sugar
The Random Sugar test is important in this case because it helps to evaluate the individual's blood glucose levels at a specific moment, which can indicate if the high creatinine level is related to uncontrolled diabetes. Elevated creatinine levels can be a sign of kidney damage, and uncontrolled diabetes can contribute to kidney dysfunction. Monitoring blood sugar levels can provide valuable information for proper management and treatment.
What is the relation between creatinine and kidney function?
Creatinine, a chemical synthesized within the body at a consistent pace, undergoes thorough filtration by the kidneys, exiting the system through urine. Whenever kidney functionality becomes compromised, for various reasons, the levels of creatinine experience a surge. Consequently, creatinine emerges as an invaluable means to assess the performance of the kidneys.
Why do doctors ask for GFR if my creatinine level is 8.4?
Glomerular Filtration Rate or GFR is the rate at which a given volume of blood is cleared of any substance every unit of time. This basically is a measure of the filtration capacity of the kidney. Even a small reduction in GFR can have consequences in patients who already have comorbidities. The GFR is calculated from the level of creatinine in the blood using a variety of equations like the MDRD equation given as follows : GFR (mL/min/1.73 m2) = 175 × (Scr)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212 if African American). Using this formula the value of GFR can be calculated just by knowing the level of creatinine in the blood.
What is my GFR if my creatinine level is 8.4?
Estimated Glomerular Filtration Rate (GFR) for a creatinine value of 8.4
| Age in Years | Estimated Glomerular Filtration Rate (GFR) | GFR Grade |
|---|---|---|
| 18 yrs | Male : 8.35 mL/min/1.73 m2 Female : 6.19 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 19 yrs | Male : 8.26 mL/min/1.73 m2 Female : 6.13 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 20 yrs | Male : 8.17 mL/min/1.73 m2 Female : 6.06 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 21 yrs | Male : 8.09 mL/min/1.73 m2 Female : 6.0 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 22 yrs | Male : 8.02 mL/min/1.73 m2 Female : 5.95 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 23 yrs | Male : 7.94 mL/min/1.73 m2 Female : 5.89 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 24 yrs | Male : 7.87 mL/min/1.73 m2 Female : 5.84 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 25 yrs | Male : 7.81 mL/min/1.73 m2 Female : 5.79 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 26 yrs | Male : 7.75 mL/min/1.73 m2 Female : 5.75 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 27 yrs | Male : 7.69 mL/min/1.73 m2 Female : 5.71 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 28 yrs | Male : 7.63 mL/min/1.73 m2 Female : 5.66 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 29 yrs | Male : 7.58 mL/min/1.73 m2 Female : 5.62 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 30 yrs | Male : 7.53 mL/min/1.73 m2 Female : 5.58 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 31 yrs | Male : 7.48 mL/min/1.73 m2 Female : 5.55 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 32 yrs | Male : 7.43 mL/min/1.73 m2 Female : 5.51 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 33 yrs | Male : 7.38 mL/min/1.73 m2 Female : 5.48 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 34 yrs | Male : 7.34 mL/min/1.73 m2 Female : 5.44 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 35 yrs | Male : 7.29 mL/min/1.73 m2 Female : 5.41 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 36 yrs | Male : 7.25 mL/min/1.73 m2 Female : 5.38 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 37 yrs | Male : 7.21 mL/min/1.73 m2 Female : 5.35 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 38 yrs | Male : 7.17 mL/min/1.73 m2 Female : 5.32 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 39 yrs | Male : 7.14 mL/min/1.73 m2 Female : 5.29 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 40 yrs | Male : 7.1 mL/min/1.73 m2 Female : 5.27 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 41 yrs | Male : 7.06 mL/min/1.73 m2 Female : 5.24 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 42 yrs | Male : 7.03 mL/min/1.73 m2 Female : 5.22 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 43 yrs | Male : 7.0 mL/min/1.73 m2 Female : 5.19 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 44 yrs | Male : 6.96 mL/min/1.73 m2 Female : 5.17 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 45 yrs | Male : 6.93 mL/min/1.73 m2 Female : 5.14 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 46 yrs | Male : 6.9 mL/min/1.73 m2 Female : 5.12 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 47 yrs | Male : 6.87 mL/min/1.73 m2 Female : 5.1 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 48 yrs | Male : 6.84 mL/min/1.73 m2 Female : 5.08 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 49 yrs | Male : 6.81 mL/min/1.73 m2 Female : 5.05 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 50 yrs | Male : 6.78 mL/min/1.73 m2 Female : 5.03 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 51 yrs | Male : 6.76 mL/min/1.73 m2 Female : 5.01 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 52 yrs | Male : 6.73 mL/min/1.73 m2 Female : 4.99 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 53 yrs | Male : 6.7 mL/min/1.73 m2 Female : 4.98 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 54 yrs | Male : 6.68 mL/min/1.73 m2 Female : 4.96 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 55 yrs | Male : 6.65 mL/min/1.73 m2 Female : 4.94 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 56 yrs | Male : 6.63 mL/min/1.73 m2 Female : 4.92 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 57 yrs | Male : 6.61 mL/min/1.73 m2 Female : 4.9 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 58 yrs | Male : 6.58 mL/min/1.73 m2 Female : 4.88 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 59 yrs | Male : 6.56 mL/min/1.73 m2 Female : 4.87 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 60 yrs | Male : 6.54 mL/min/1.73 m2 Female : 4.85 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 61 yrs | Male : 6.52 mL/min/1.73 m2 Female : 4.84 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 62 yrs | Male : 6.49 mL/min/1.73 m2 Female : 4.82 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 63 yrs | Male : 6.47 mL/min/1.73 m2 Female : 4.8 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 64 yrs | Male : 6.45 mL/min/1.73 m2 Female : 4.79 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 65 yrs | Male : 6.43 mL/min/1.73 m2 Female : 4.77 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 66 yrs | Male : 6.41 mL/min/1.73 m2 Female : 4.76 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 67 yrs | Male : 6.39 mL/min/1.73 m2 Female : 4.74 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 68 yrs | Male : 6.37 mL/min/1.73 m2 Female : 4.73 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 69 yrs | Male : 6.36 mL/min/1.73 m2 Female : 4.72 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 70 yrs | Male : 6.34 mL/min/1.73 m2 Female : 4.7 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 71 yrs | Male : 6.32 mL/min/1.73 m2 Female : 4.69 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 72 yrs | Male : 6.3 mL/min/1.73 m2 Female : 4.68 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 73 yrs | Male : 6.28 mL/min/1.73 m2 Female : 4.66 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 74 yrs | Male : 6.27 mL/min/1.73 m2 Female : 4.65 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 75 yrs | Male : 6.25 mL/min/1.73 m2 Female : 4.64 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 76 yrs | Male : 6.23 mL/min/1.73 m2 Female : 4.62 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 77 yrs | Male : 6.22 mL/min/1.73 m2 Female : 4.61 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 78 yrs | Male : 6.2 mL/min/1.73 m2 Female : 4.6 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 79 yrs | Male : 6.18 mL/min/1.73 m2 Female : 4.59 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 80 yrs | Male : 6.17 mL/min/1.73 m2 Female : 4.58 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 81 yrs | Male : 6.15 mL/min/1.73 m2 Female : 4.56 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 82 yrs | Male : 6.14 mL/min/1.73 m2 Female : 4.55 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 83 yrs | Male : 6.12 mL/min/1.73 m2 Female : 4.54 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 84 yrs | Male : 6.11 mL/min/1.73 m2 Female : 4.53 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 85 yrs | Male : 6.09 mL/min/1.73 m2 Female : 4.52 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 86 yrs | Male : 6.08 mL/min/1.73 m2 Female : 4.51 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 87 yrs | Male : 6.06 mL/min/1.73 m2 Female : 4.5 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 88 yrs | Male : 6.05 mL/min/1.73 m2 Female : 4.49 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 89 yrs | Male : 6.04 mL/min/1.73 m2 Female : 4.48 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 90 yrs | Male : 6.02 mL/min/1.73 m2 Female : 4.47 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 91 yrs | Male : 6.01 mL/min/1.73 m2 Female : 4.46 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 92 yrs | Male : 5.99 mL/min/1.73 m2 Female : 4.45 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 93 yrs | Male : 5.98 mL/min/1.73 m2 Female : 4.44 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 94 yrs | Male : 5.97 mL/min/1.73 m2 Female : 4.43 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
| 95 yrs | Male : 5.96 mL/min/1.73 m2 Female : 4.42 mL/min/1.73 m2 | GFR Grade G5 : Kidney Failure |
References
Authorotative articles on serum creatinine
Recommended Tests
The following tests are recommeded as additional investigations for a creatinine of 8.4
HBA1C
Visit HBA1C Test to know more
Electrolytes
Visit Electrolytes to know more
Kidney Profile
Visit Kidney Profile to know more
Reviewed By - Dr.Bhargav Raut
Dr.Bhargav Raut is a qualified Pathologist, with over 5 years of experience in the field
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